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As an illustration, human SET7/9 has not too long ago been reported to methylate Lys189 in the general transcription issue TAF10, solicitor law firm leading to an increased affinity for RNA polymerase II and transcriptional activation of certain TAF10-dependent genes 37 SET7/9 has also been reported to methylate p53, growing the stability of this quick lived tumor-suppressor protein 38 These observations suggest that we should not narrowly define the SET-domain proteins as histone lysine methyltransferases however as an alternative name them protein lysine methyltransferases.
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